2413293-65-7

2413293-65-7 structure

Name: Antibacterial agent 102
Chemical Name: Antibacterial agent 102
CAS Number: 2413293-65-7
Molecular Formula: C₃₅H₄₉N₅O₅S
Molecular Weight: 651.86
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-02 16:59:50
Modify Date: 2024-01-10 19:25:29
Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC50 value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice[1].

Name	Antibacterial agent 102

Description	Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC50 value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: < 0.5 μg/mL (S. aureus)[1] IC50: 6.148 μM (CYP3A4)[1]
References	[1]. Zhang Z, et al. Design, synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents. Eur J Med Chem. 2020;204:112604.

Molecular Formula	C₃₅H₄₉N₅O₅S
Molecular Weight	651.86