2616813-99-9

2616813-99-9 structure

Name: BRG1-IN-1
Chemical Name: BRG1-IN-1
CAS Number: 2616813-99-9
Molecular Formula: C₂₀H₁₉FN₂O
Molecular Weight: 322.38
Catalog: Research Areas Cancer
Create Date: 2022-08-20 20:50:39
Modify Date: 2024-09-11 19:08:24
BRG1-IN-1 (Compound 11d) is a potent inhibitor of BRG1. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors[1].

Name	BRG1-IN-1

Description	BRG1-IN-1 (Compound 11d) is a potent inhibitor of BRG1. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. He Y, et al. Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells. Bioorg Med Chem. 2022 Jan 1;53:116533.

Molecular Formula	C₂₀H₁₉FN₂O
Molecular Weight	322.38