2418549-32-1

2418549-32-1 structure

Name: EGFR-IN-51
Chemical Name: EGFR-IN-51
CAS Number: 2418549-32-1
Molecular Formula: C₂₁H₁₅N₃O₂S
Molecular Weight: 373.43
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-02 12:56:20
Modify Date: 2024-01-19 11:45:50
EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

Name	EGFR-IN-51

Description	EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.493 μM (IC50) EGFRL858R:102.60 μM (IC50) EGFRT790M:461.63 μM (IC50)
References	[1]. Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.

Molecular Formula	C₂₁H₁₅N₃O₂S
Molecular Weight	373.43