2057423-46-6

2057423-46-6 structure

Name: EGFR-IN-55
Chemical Name: EGFR-IN-55
CAS Number: 2057423-46-6
Molecular Formula: C₂₅H₂₅Cl₂N₇O₂
Molecular Weight: 526.42
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-07-01 12:10:17
Modify Date: 2024-01-05 22:17:54
EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

Name	EGFR-IN-55

Description	EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFRL858R/T790M:3.9 nM (IC50) EGFRWT:70 nM (IC50)
References	[1]. Shao J, et al. Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg Med Chem. 2020 Oct 1;28(19):115680.

Molecular Formula	C₂₅H₂₅Cl₂N₇O₂
Molecular Weight	526.42