2396664-85-8

2396664-85-8 structure

2396664-85-8 structure

Name: FGFR4-IN-11
Chemical Name: FGFR4-IN-11
CAS Number: 2396664-85-8
Molecular Formula: C₂₉H₂₉N₅O₅
Molecular Weight: 527.57
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2022-07-29 14:02:27
Modify Date: 2024-01-16 07:48:09
FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].

Name	FGFR4-IN-11

Description	FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR4:2.1 nM (IC50)
References	[1]. Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65(10):7278-7295.

Molecular Formula	C₂₉H₂₉N₅O₅
Molecular Weight	527.57