2133818-85-4
2133818-85-4 structure
- Name: Influenza virus-IN-4
- Chemical Name: Influenza virus-IN-4
- CAS Number: 2133818-85-4
- Molecular Formula: C23H31FN2O4
- Molecular Weight: 418.50
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2022-07-01 13:08:05
- Modify Date: 2024-01-02 12:58:02
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Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1].
| Name | Influenza virus-IN-4 |
|---|
| Description | Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1]. |
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| Related Catalog | |
| Target |
IC50: 3.4 µM (H5N1); 0.094 µM (H5N2); 0.79 µM (H5N6); 0.077 µM (H5N8)[1] |
| In Vitro | Influenza virus-IN-4 (compound 11e) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 33.26, 16.81, 45.46, 33.02, 5270.33, 0.00043, 0.00347 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1]. |
| References |
| Molecular Formula | C23H31FN2O4 |
|---|---|
| Molecular Weight | 418.50 |