2556833-08-8

2556833-08-8 structure

2556833-08-8 structure

Name: mGAT-IN-1
Chemical Name: mGAT-IN-1
CAS Number: 2556833-08-8
Molecular Formula: C₂₈H₃₄ClN₃O₂S₂
Molecular Weight: 544.17
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2022-07-02 16:22:03
Modify Date: 2024-01-03 18:44:23
mGAT-IN-1 (compound 28) is a potent and non-selective GAT inhibitor. mGAT-IN-1 has a high inhibitory potency toward mGAT3, with an IC50 of 2.5 μM and pIC50 of 5.61[1].

Name	mGAT-IN-1

Description	mGAT-IN-1 (compound 28) is a potent and non-selective GAT inhibitor. mGAT-IN-1 has a high inhibitory potency toward mGAT3, with an IC50 of 2.5 μM and pIC50 of 5.61[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	IC50: 2.5 μM (mGAT3); pIC50: 5.06 ± 0.02 (mGAT1), 5.35 ± 0.08 (mGAT2), 5.61 ± 0.07 (mGAT3), 5.21 ± 0.05 (mGAT4)[1]
References	[1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

Molecular Formula	C₂₈H₃₄ClN₃O₂S₂
Molecular Weight	544.17