2519450-32-7

2519450-32-7 structure

Name: PDE4-IN-9
Chemical Name: PDE4-IN-9
CAS Number: 2519450-32-7
Molecular Formula: C₁₅H₁₂N₄O₃S
Molecular Weight: 328.35
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-07-01 17:58:32
Modify Date: 2024-01-14 19:40:51
PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].

Name	PDE4-IN-9

Description	PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Lin Y, et al. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors. Eur J Med Chem. 2020 Dec 1;207:112795.

Molecular Formula	C₁₅H₁₂N₄O₃S
Molecular Weight	328.35