2668297-70-7

2668297-70-7 structure

Name: ZDWX-25
Chemical Name: ZDWX-25
CAS Number: 2668297-70-7
Molecular Formula: C₁₇H₁₅N₃O₃
Molecular Weight: 309.32
Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
Create Date: 2022-07-01 21:07:10
Modify Date: 2024-03-10 21:20:22
ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease[1].

Name	ZDWX-25

Description	ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β:71 nM (IC50)
References	[1]. Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095.

Molecular Formula	C₁₇H₁₅N₃O₃
Molecular Weight	309.32