1803040-07-4

1803040-07-4 structure

1803040-07-4 structure

Name: 20S Proteasome-IN-3
Chemical Name: 20S Proteasome-IN-3
CAS Number: 1803040-07-4
Molecular Formula: C₃₄H₄₃N₃O₈
Molecular Weight: 621.72
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2022-08-03 20:02:18
Modify Date: 2024-01-02 20:28:41
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM)[1][2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity[2].

Name	20S Proteasome-IN-3

Description	20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM)[1][2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
Target	IC50: 1.64 μM (20S proteasome β5 subunit)[1]
In Vitro	20S Proteasome-IN-3 (Compound 10b) (5.34-9.69 μM, 18-24 h) exhibits significant inhibition against A375, SW480, DU145, and HeLa cells[2]. Cell Proliferation Assay[2] Cell Line: A375, SW480, DU145, and HeLa cell lines Concentration: 5.34-9.69 μM Incubation Time: 18-24 hours Result: Inhibited the proliferation of SW480, DU145, A375 and HeLa cells with the IC50s of 5.34, 9.69, 5.66 and 7.03 μM, respectively.
References	[1]. Qi Sun, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15;192:112160. [2]. Qi Sun, et al. Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors. ChemMedChem. 2015 Mar;10(3):498-510.

Molecular Formula	C₃₄H₄₃N₃O₈
Molecular Weight	621.72