1852451-96-7
1852451-96-7 structure
- Name: AMPK activator 8
- Chemical Name: AMPK activator 8
- CAS Number: 1852451-96-7
- Molecular Formula: C25H21ClN2O6
- Molecular Weight: 480.90
- Catalog: Signaling Pathways Epigenetics AMPK
- Create Date: 2022-08-04 18:33:56
- Modify Date: 2024-01-23 19:17:59
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AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes[1].
| Name | AMPK activator 8 |
|---|
| Description | AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes[1]. |
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| Related Catalog | |
| In Vitro | AMPK activator 8 (compound 2) acts on rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ and rAMPK α2β2γ3 with the EC50 value of 11 nM, 27 nM, 4 nM, 2 nM and 4 nM, respectively[1]. AMPK activator 8 (compound 2) affects cell viability[1]. Cell Viability Assay[1] Cell Line: HepG2, C2C12 myoblasts Concentration: 0.01-1000 μM Incubation Time: 1 hour Result: Resulted in HepG2 and C2C12 myoblasts with the EC50 value of 255 nM and 230 nM, respectively. |
| References |
[1]. Mathilde Muzerelle, et al. Novel activators of amp-activated protein kinases.WO2016001224A1 |
| Molecular Formula | C25H21ClN2O6 |
|---|---|
| Molecular Weight | 480.90 |