2417651-42-2

2417651-42-2 structure

Name: Antitumor agent-69
Chemical Name: Antitumor agent-69
CAS Number: 2417651-42-2
Molecular Formula: C₄₃H₆₂N₈O₅
Molecular Weight: 771.00
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2022-08-12 14:33:25
Modify Date: 2024-01-03 08:58:01
Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy[1].

Name	Antitumor agent-69

Description	Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
References	[1]. Yuan Y, et, al. Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem. 2022 Jun 9;65(11):7770-7785.

Molecular Formula	C₄₃H₆₂N₈O₅
Molecular Weight	771.00