2444364-04-7

2444364-04-7 structure

Name: EGFR/HER2/TS-IN-2
Chemical Name: EGFR/HER2/TS-IN-2
CAS Number: 2444364-04-7
Molecular Formula: C₂₆H₂₁N₇OS₂
Molecular Weight: 511.62
Catalog: Signaling Pathways Apoptosis Thymidylate Synthase
Create Date: 2022-08-12 16:45:13
Modify Date: 2024-01-28 11:46:26
EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].

Name	EGFR/HER2/TS-IN-2

Description	EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Thymidylate Synthase Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.173 ± 0. μM (IC50) HER2:0.125 ± 0. μM (IC50)
In Vitro	EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively[1].
References	[1]. Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.

Molecular Formula	C₂₆H₂₁N₇OS₂
Molecular Weight	511.62