1802891-23-1

1802891-23-1 structure

Name: Human enteropeptidase-IN-1
Chemical Name: Human enteropeptidase-IN-1
CAS Number: 1802891-23-1
Molecular Formula: C₂₀H₁₈N₄O₇
Molecular Weight: 426.38
Catalog: Research Areas Metabolic Disease
Create Date: 2022-08-24 08:04:41
Modify Date: 2024-01-28 11:12:42
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research[1].

Name	Human enteropeptidase-IN-1

Description	Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50(initial): 20 nM (enteropeptidase)[1] IC50(app): 1.2 nM (enteropeptidase)[1]
In Vitro	Human enteropeptidase-IN-1 (compound 6b) has inhibitory activity against enteropeptidase with IC50(initial)* of 20 nM and IC50(app)** of 1.2 nM[1]. (IC50(initial) refers to the inhibitory activity of human enteropeptidase after 6 min of incubation with the enzyme, substrate, and compound. *IC50(app) refers to the apparent IC50 value after 120 min of incubation with the enzyme, substrate, and compound.)
References	[1]. Ikeda Z, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65(12):8456-8477.

Molecular Formula	C₂₀H₁₈N₄O₇
Molecular Weight	426.38