2636771-45-2

2636771-45-2 structure

Name: IZTZ-1
Chemical Name: IZTZ-1
CAS Number: 2636771-45-2
Molecular Formula: C₃₂H₃₅N₇S
Molecular Weight: 549.73
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-11 13:03:34
Modify Date: 2024-02-04 10:15:28
IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].

Name	IZTZ-1

Description	IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> c-Myc
In Vivo	IZTZ-1 (0-20 mg/kg, IP, once every two days, for 10 days) effectively inhibits tumor growth in a melanoma mouse model[1].
References	[1]. Wu TY, et al. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Jun;99:103866.

Molecular Formula	C₃₂H₃₅N₇S
Molecular Weight	549.73