2757155-96-5

2757155-96-5 structure

Name: mIDH1-IN-1
Chemical Name: mIDH1-IN-1
CAS Number: 2757155-96-5
Molecular Formula: C₂₅H₂₇N₃O₅
Molecular Weight: 449.50
Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
Create Date: 2022-08-02 19:01:52
Modify Date: 2024-01-09 16:27:36
mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1].

Name	mIDH1-IN-1

Description	mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
Target	IC50: 961.5 ± 25.3 nM (IDH1R132H); EC50: 208.6 ± 8.0 nM (2-HG)[1]
References	[1]. Zhou X, et al. Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction. Bioorg Chem. 2022 Feb;119:105569.

Molecular Formula	C₂₅H₂₇N₃O₅
Molecular Weight	449.50