2641484-61-7

2641484-61-7 structure

Name: MK-0159
Chemical Name: MK-0159
CAS Number: 2641484-61-7
Molecular Formula: C₂₀H₂₄N₄O₃S
Molecular Weight: 400.49
Catalog: Research Areas Cardiovascular Disease
Create Date: 2022-08-25 17:49:33
Modify Date: 2024-09-21 19:28:23
MK-0159 (compound 37) is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1].

Name	MK-0159

Description	MK-0159 (compound 37) is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
Target	IC50: 3 nM (mouse CD38), 22 ± 5 nM (hCD38), 70 nM (rat CD38)[1]
References	[1]. Lagu B, et al. Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart. J Med Chem. 2022 Jun 28.

Molecular Formula	C₂₀H₂₄N₄O₃S
Molecular Weight	400.49