2374122-27-5
2374122-27-5 structure
- Name: PROTAC IRAK4 degrader-2
- Chemical Name: PROTAC IRAK4 degrader-2
- CAS Number: 2374122-27-5
- Molecular Formula: C57H68FN11O8S
- Molecular Weight: 1086.28
- Catalog: Signaling Pathways Immunology/Inflammation IRAK
- Create Date: 2022-08-14 10:08:30
- Modify Date: 2024-01-13 16:40:29
-
PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs[1].
| Name | PROTAC IRAK4 degrader-2 |
|---|
| Description | PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PROTAC IRAK4 degrader-2 (compound 9) (0.01~10 μM; 22 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner[1]. PROTAC IRAK4 degrader-2 (compound 9) (0.01~10 μM; 24 hours; PBMCs) induces a reduction of IRAK4 protein levels[1]. Western Blot Analysis[1] Cell Line: PBMCs Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3 and 10 μM Incubation Time: 22 and 24 hours Result: Induced a reduction of IRAK4 protein levels with a DC50 value of 36 nM and IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner. |
| References |
| Molecular Formula | C57H68FN11O8S |
|---|---|
| Molecular Weight | 1086.28 |