1965323-05-0
1965323-05-0 structure
- Name: Syk Inhibitor II dihydrochloride dihydrate
- Chemical Name: Syk Inhibitor II dihydrochloride dihydrate
- CAS Number: 1965323-05-0
- Molecular Formula: C14H21Cl2F3N6O3
- Molecular Weight: 449.26
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2022-08-14 21:52:52
- Modify Date: 2024-02-04 05:54:07
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Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect[1].
| Name | Syk Inhibitor II dihydrochloride dihydrate |
|---|
| Description | Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect[1]. |
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| Related Catalog | |
| Target |
serotonin:460 nM (IC50) Syk:41 nM (IC50) PKCε:5.1 μM (IC50) PKCβ2:11 μM (IC50) ZAP-70:11.2 μM (IC50) Btk:15.5 μM (IC50) Itk:22.6 μM (IC50) |
| In Vitro | Syk Inhibitor II (compound 9a) dihydrochloride dihydrate shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1]. |
| In Vivo | Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride dihydrate is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1]. |
| References |
| Molecular Formula | C14H21Cl2F3N6O3 |
|---|---|
| Molecular Weight | 449.26 |