Shanghai Nianxing Industrial Co., Ltd
China
Product Name: WAY-324883
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Purity: 98.0%
Stocking Period: 10 Day
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694466-00-7

694466-00-7 structure

Name: hCAI/II-IN-6
Chemical Name: 694466-00-7
CAS Number: 694466-00-7
Molecular Formula: C₁₉H₂₄N₄O₃S
Molecular Weight: 388.49
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-10-13 19:01:18
Modify Date: 2024-09-14 23:17:46
hCAI/II-IN-6 is a human carbonic anhydrase(CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy[1].

Name	694466-00-7

Description	hCAI/II-IN-6 is a human carbonic anhydrase(CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Neurological Disease
In Vitro	hCAI/II-IN-6 (0-50 μM) inhibits hCA I, hCA II , hCA VII and hCA XII activities with Ki values of 220, 4.9, 6.5 and ＞50000 nM, respectively[1].
In Vivo	hCAI/II-IN-6 (30-100mg/kg; i.p. once) shows good anticonvulsant effect in vivo[1]. hCAI/II-IN-6 (30 mg/kg; p.o. once) shows anti-MES activity in vivo[1]. Animal Model: Swiss albino mice[1] Dosage: 30 and 100 mg/kg Administration: Intraperitoneal injection; 30-100 mg/kg once Result: Provided seizure attenuation and good anticonvulsant effect, and showed an ED50 of 13.7mg/kg in anticonvulsant quantification study. Animal Model: Wistar albino rats[1] Dosage: 30 mg/kg Administration: Oral gavage; 30 mg/kg once Result: Showed anti-MES activity and significant protection from seizures up to 1h of drug administration and action was gone reduced after 1h.
References	[1]. Mishra CB, et al. Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. J Med Chem. 2017 Mar 23;60(6):2456-2469.

Molecular Formula	C₁₉H₂₄N₄O₃S
Molecular Weight	388.49
Storage condition	-20°C

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