Shanghai Nianxing Industrial Co., Ltd
China
Product Name: JNJ-1289
Price:
Purity: 98.16%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: JNJ-1289
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

792898-18-1

792898-18-1 structure

792898-18-1 structure

Name: JNJ-1289
Chemical Name: JNJ-1289
CAS Number: 792898-18-1
Molecular Formula: C₁₆H₁₂N₄OS
Molecular Weight: 308.36
Catalog: Research Areas Cancer
Create Date: 2022-09-25 11:36:10
Modify Date: 2023-02-10 12:50:31
JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].

Name	JNJ-1289

Description	JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 50 nM (hSMOX)[1]; >2 μM (hPAOX and LSD1)[1].
In Vitro	JNJ-1289 (0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1]. JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1].
References	[1]. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787.

Molecular Formula	C₁₆H₁₂N₄OS
Molecular Weight	308.36