907957-34-0

907957-34-0 structure

Name: NSC 694623
Chemical Name: NSC 694623
CAS Number: 907957-34-0
Molecular Formula: C₁₆H₁₆N₂OS
Molecular Weight: 284.38
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2022-09-12 08:43:15
Modify Date: 2024-01-10 21:26:37
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer[1].

Name	NSC 694623

Description	NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	PCAF:15.9 μM (IC50)
In Vitro	NSC 694623 has antiproliferative activity against SK-N-SH with an IC50 of 8.93 μM, and inhibits 21% of HCT116 at 25 μM[1].
References	[1]. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.

Molecular Formula	C₁₆H₁₆N₂OS
Molecular Weight	284.38