667411-04-3

667411-04-3 structure

Name: TRPM4-IN-2
Chemical Name: TRPM4-IN-2
CAS Number: 667411-04-3
Molecular Formula: C₁₉H₁₄ClNO₄
Molecular Weight: 355.77
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2022-09-04 17:36:08
Modify Date: 2024-01-14 19:26:56
TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

Name	TRPM4-IN-2

Description	TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer
Target	TRPM4:0.16 μM (IC50)
In Vitro	TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1]. Cell Proliferation Assay[1] Cell Line: DU145 Concentration: 50 μM Incubation Time: 0-500 s Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
References	[1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. [2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400.

Molecular Formula	C₁₉H₁₄ClNO₄
Molecular Weight	355.77