Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Propen-1-one,1-(4-hydroxyphenyl)-3-phenyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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2657-25-2

2657-25-2 structure

Name: 2-Benzal-4-hydroxyacetophenone
Chemical Name: 4'-hydroxychalcone
CAS Number: 2657-25-2
Molecular Formula: C₁₅H₁₂O₂
Molecular Weight: 224.25500
Catalog: Biochemical Plant extracts
Create Date: 2018-03-12 08:00:00
Modify Date: 2024-01-03 03:18:55
4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].

Name	4'-hydroxychalcone
Synonyms	MFCD00016484 2-BENZAL-4'-HYDROXYACETOPHENONE BENZYLIDENE-4'-HYDROXYACETOPHENONE 4'-HYDROXYCHALCONE HYDROXYCHALCONE,4' 4′-Hydroxychalcone 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 2-Benzylidene-4'-hydroxyacetophenone

Description	4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54. [2]. Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2). [3]. Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31.

Density	1.191 g/cm3
Boiling Point	419.6ºC at 760 mmHg
Melting Point	174-178 °C
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Flash Point	179.1ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Vapour Pressure	1.23E-07mmHg at 25°C
Index of Refraction	1.653

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26

100-52-7

99-93-4

~98%

2657-25-2

Literature: Rafiee, Ezzat; Rahimi, Farzaneh Monatshefte fur Chemie, 2013 , vol. 144, # 3 p. 361 - 367

22966-19-4

~99%

2657-25-2

Literature: Gavande, Navnath S.; Kundu, Sonia; Badgujar, Naresh S.; Kaur, Gurmeet; Chakraborti, Asit K. Tetrahedron, 2006 , vol. 62, # 17 p. 4201 - 4204

99-93-4

2657-25-2

Literature: Manna, Fedele; Chimenti, Franco; Fioravanti, Rossella; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; Ferlini, Cristiano; Scambia, Giovanni Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4632 - 4635

468060-22-2

~16%

2657-25-2

Literature: Liu; Wilairat; Go Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4443 - 4452

16162-69-9

100-52-7

~84%

2657-25-2

Literature: Lin, Chun-Nan; Lee, Tai-Hua; Hsu, Mei-Feng; Wang, Jih-Pyang; Ko, Feng-Nien; Teng, Che-Ming Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 5 p. 530 - 536

16162-69-9

2657-25-2

Literature: Sogawa; Nihro; Ueda; Izumi; Miki; Matsumoto; Satoh Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3904 - 3909

140-10-3

108-95-2

2657-25-2

Literature: Nakazawa et al. Yakugaku Zasshi, 1954 , vol. 74, p. 495 Chem.Abstr., 1955 , p. 8182

2757-04-2

888-12-0

2657-25-2

Literature: Singh, A.K.; Raghuraman, T.S. Tetrahedron Letters, 1985 , vol. 26, # 34 p. 4125 - 4128

Precursor 7
100-52-7 99-93-4 22966-19-4 16162-69-9
140-10-3 108-95-2 2757-04-2
DownStream 9
19882-38-3 614-47-1 100-52-7 99-93-4
2515-57-3 21148-30-1 64820-41-3 61078-51-1
61270-17-5

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