Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-β-d-ARABINOFURANOSYL-2′,3′,5′-TRIACETATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

6742-07-0

6742-07-0 structure

Name: 1-β-d-ARABINOFURANOSYL-2′,3′,5′-TRIACETATE
Chemical Name: [3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
CAS Number: 6742-07-0
Molecular Formula: C₁₅H₁₉N₃O₈
Molecular Weight: 369.32700
Create Date: 2017-06-02 12:47:12
Modify Date: 2024-01-09 21:06:22

Name	[3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
Synonyms	triacetylcytarabine 2',3',5'-tri-O-acetyl-arabinofuranosyl-cytidine AraC 2',3',5'-tri-O-acetyl ester

Density	1.52g/cm3
Boiling Point	507.4ºC at 760 mmHg
Molecular Formula	C₁₅H₁₉N₃O₈
Molecular Weight	369.32700
Flash Point	260.6ºC
Exact Mass	369.11700
PSA	149.04000
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5600000

CHEMICAL NAME :: Cytosine, 1-beta-D-arabino-furanosyl-, 2',3',5'-triacetate

CAS REGISTRY NUMBER :: 6742-07-0

LAST UPDATED :: 199606

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C15-H19-N3-O8

MOLECULAR WEIGHT :: 369.37

WISWESSER LINE NOTATION :: T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5010 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 750 mg/kg/15D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 3 gm/kg/15D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes primarily in glomeruli Blood - thrombocytopenia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 750 mg/kg/15D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 49 umol/L

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984

25130-27-2

~90%

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Literature: Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780

6742-08-1

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Literature: Bobek; Kavai; Sharma; Grill; Dutschman; Cheng Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2154 - 2157

69-74-9

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Literature: Bobek; Kavai; Sharma; Grill; Dutschman; Cheng Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2154 - 2157