1416771-72-6

1416771-72-6 structure

Name: Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride
Chemical Name: Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride
CAS Number: 1416771-72-6
Molecular Formula: C₁₃H₂₄ClNO₉
Molecular Weight: 373.78
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2022-10-12 01:16:23
Modify Date: 2024-04-02 21:44:29
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride

Description	Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2. [2]. David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2.

Molecular Formula	C₁₃H₂₄ClNO₉
Molecular Weight	373.78