2423045-06-9
2423045-06-9 structure
- Name: CDK9/10/GSK3β-IN-1
- Chemical Name: CDK9/10/GSK3β-IN-1
- CAS Number: 2423045-06-9
- Molecular Formula: C29H24ClN3O4S
- Molecular Weight: 546.04
- Catalog: Research Areas Cancer
- Create Date: 2022-10-22 18:13:53
- Modify Date: 2024-01-10 23:51:50
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CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 µM) and HsCDK2/CyclinA (IC50=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines[1].
| Name | CDK9/10/GSK3β-IN-1 |
|---|
| Description | CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 µM) and HsCDK2/CyclinA (IC50=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines[1]. |
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| Related Catalog | |
| Target |
IC50: 59 nM (HsGSK3β), 64 nM (HsCDK9/CyclinT), 1.093 µM (HsCDK5/p25), 1.725 µM (HsCDK2/CyclinA)[1]. |
| In Vitro | CDK9/10/GSK3β-IN-1 (series concentration,72 h) exhibits high antiproliferative activity to SKOV3, NCIeN87, SKBR3, PC3, MiaPaCa-2, HCT116, K562 cells[1]. Cell Proliferation Assay[1] Cell Line: SKOV3, NCIeN87, SKBR3, PC3, MiaPaCa-2, HCT116, K562 cells Concentration: Series concentration Incubation Time: 72 h Result: Showed high antiproliferative activity, with an IC50 < 100 nM on 6 cancer cell lines, and up to six times more potent on the pancreatic cancer cells (MiaPaCa-2) than the reference compound, flavopiridol. |
| References |
| Molecular Formula | C29H24ClN3O4S |
|---|---|
| Molecular Weight | 546.04 |