186033-14-7
186033-14-7 structure
- Name: NS-8
- Chemical Name: NS-8
- CAS Number: 186033-14-7
- Molecular Formula: C12H10FN3
- Molecular Weight: 215.23
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2022-10-16 09:44:04
- Modify Date: 2024-04-05 19:21:06
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NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].
| Name | NS-8 |
|---|
| Description | NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1]. |
|---|---|
| Related Catalog | |
| In Vivo | NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1]. Animal Model: Rats[1] Dosage: 1, 3 and 10 mg/kg Administration: Intraduodenal administration, intravenous injection Result: Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure). Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude. Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure. |
| References |
| Molecular Formula | C12H10FN3 |
|---|---|
| Molecular Weight | 215.23 |