2365241-79-6
2365241-79-6 structure
- Name: PI4KIIIbeta-IN-11
- Chemical Name: PI4KIIIbeta-IN-11
- CAS Number: 2365241-79-6
- Molecular Formula: C33H39N7O3
- Molecular Weight: 581.71
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI4K
- Create Date: 2022-10-15 16:23:48
- Modify Date: 2024-01-19 17:01:00
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PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2].
| Name | PI4KIIIbeta-IN-11 |
|---|
| Description | PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PI4KIIIβ:9.1 (pIC50) |
| In Vitro | PI4KIIIβ may be a relevant target protein for inhibition of Hedgehog signaling, and regulates trafficking from the Golgi system to the plasma membrane[1]. PI4KIIIbeta-IN-11 (compound 22) (0.5 μM; 0-45 min) shows metabolic stability in human microsomes, with the intrinsic clearance of 33.7 mL/min/g[2]. |
| In Vivo | PI4KIIIbeta-IN-11 (compound 22) (1 mg/kg; i.v.; last over 1 h) displays a low spleen concentration in rats[2]. Animal Model: Male Wistar Han Rats[2] Dosage: 1 mg/kg Administration: Intravenous injection, formulated in 2% DMSO in Kleptose (aq, 10% w/v); over 1 hour; euthanised at 12 h Result: Showed a low concentration in spleen of 5.54 ng/g. |
| References |
| Molecular Formula | C33H39N7O3 |
|---|---|
| Molecular Weight | 581.71 |