2665669-32-7

2665669-32-7 structure

2665669-32-7 structure

Name: RIPK3-IN-2
Chemical Name: RIPK3-IN-2
CAS Number: 2665669-32-7
Molecular Formula: C₂₁H₁₆ClN₃O₂S₂
Molecular Weight: 441.95
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2022-10-15 23:11:30
Modify Date: 2024-01-13 18:13:05
RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research[1].

Name	RIPK3-IN-2

Description	RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase
In Vitro	RIPK3-IN-2 (0.3-20 μM; 42 h) inhibits HT-29 cell growth[1]. RIPK3-IN-2 (0.3-20 μM; 14 h) inhibits MEF cell growth[1]. RIPK3-IN-2 (0.3-20 μM; 18 h) inhibits L929 cell growth[1]. Cell Viability Assay[1] Cell Line: HT-29 cells Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM Incubation Time: 42 hours Result: Showed EC50 value of 0.085 μM. Cell Viability Assay[1] Cell Line: MEF cells Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM Incubation Time: 14 hours Result: Showed EC50 value of 0.24 μM. Cell Viability Assay[1] Cell Line: L929 cells Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM Incubation Time: 18 hours Result: Showed EC50 value of 0.21 μM.
References	[1]. Xiaohu Zhang, et al. Heteroaryl compounds as inhibitors of programmed necrosis pathway, composition and method using the same. WO2021138694A1

Molecular Formula	C₂₁H₁₆ClN₃O₂S₂
Molecular Weight	441.95