910582-16-0

910582-16-0 structure

Name: ZIKV-IN-2
Chemical Name: ZIKV-IN-2
CAS Number: 910582-16-0
Molecular Formula: C₃₉H₄₂O₄
Molecular Weight: 574.75
Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
Create Date: 2022-10-10 07:13:12
Modify Date: 2024-04-06 00:18:17
ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV)[1].

Name	ZIKV-IN-2

Description	ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	IC50: 38.86 μM (MTase)[1]
In Vitro	ZIKV-IN-2 (compound 3a; 0.08-50 μM) inhibits the expression of ZIKV E protein with an EC50 value of 6.17 μM and inhibits ZIKV replication and infection[1]. ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells[1]. Cell Viability Assay[1] Cell Line: Vero, Huh7 and A549 cells Concentration: 0.08, 0.4, 2, 10, and 50 μM Incubation Time: 96 hours Result: Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC50>200 μM to all three cell lines.
References	[1]. Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710.

Molecular Formula	C₃₉H₄₂O₄
Molecular Weight	574.75