1435938-24-1
1435938-24-1 structure
- Name: Quetiapine hemifumarate-d8
- Chemical Name: Quetiapine-D8 hemifumarate solution
- CAS Number: 1435938-24-1
- Molecular Formula: (C21D8H17N3O2S)2·C4H4O4
- Molecular Weight: 899.18
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2022-11-21 15:49:38
- Modify Date: 2024-01-09 18:33:25
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Quetiapine (hemifumarate)-d8 is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].
| Name | Quetiapine-D8 hemifumarate solution |
|---|---|
| Synonyms | EINECS 200-659-6 |
| Description | Quetiapine (hemifumarate)-d8 is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Molecular Formula | (C21D8H17N3O2S)2·C4H4O4 |
|---|---|
| Molecular Weight | 899.18 |