1149339-78-5
1149339-78-5 structure
- Name: TMX-201
- Chemical Name: TMX-201
- CAS Number: 1149339-78-5
- Molecular Formula: C57H93N6O12P
- Molecular Weight: 1085.36
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2022-12-01 13:04:54
- Modify Date: 2024-01-23 18:24:19
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TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research[1].
| Name | TMX-201 |
|---|
| Description | TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research[1]. |
|---|---|
| Related Catalog | |
| Target |
TLR7 |
| In Vitro | TMX-201 is more potent cytokine inducer than Imiquimod (HY-B0180) in both mouse and human mononuclear cells. TMX-201 shows less off-target binding compared to Imiquimod[1]. |
| In Vivo | The maximum tolerated dose of TMX-201 by i.v. administration is 75 mg/kg[1]. TMX-201 (4mg/kg, IP) suppresses the growth of established subcutaneous B16 melanoma by 46%, without discernible adverse effects[1]. TMX-201 (IP or intra-tumor administration), in combination with anti-CTLA4 antibody, significantly suppressed lung metastasis formation in the 4T1 breast cancer model[1]. |
| References |
| Molecular Formula | C57H93N6O12P |
|---|---|
| Molecular Weight | 1085.36 |