946415-13-0

946415-13-0 structure
946415-13-0 structure
  • Name: FG-3019
  • Chemical Name: FG-3019
  • CAS Number: 946415-13-0
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2023-02-13 08:58:59
  • Modify Date: 2024-01-03 17:21:10
  • FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].

Name FG-3019
Description FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].
Related Catalog
In Vivo FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) 与 Gemcitabine 联合使用可显着降低小鼠胰腺导管腺癌 (PDA) 的生长,并诱导 LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) 小鼠中的肿瘤细胞凋亡[2]。
References

[1]. Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777.  

[2]. Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30.  

No Any Chemical & Physical Properties