1242862-71-0

1242862-71-0 structure

Name: FUBP1-IN-2
Chemical Name: FUBP1-IN-2
CAS Number: 1242862-71-0
Molecular Formula: C₂₆H₂₆ClN₃O₄
Molecular Weight: 479.96
Catalog: Signaling Pathways Apoptosis c-Myc
Create Date: 2023-01-22 16:42:20
Modify Date: 2024-01-11 19:00:45
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

Name	FUBP1-IN-2

Description	FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> c-Myc
In Vitro	FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].
References	[1]. Dobrovolskaite A, et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. J Med Chem. 2022 Nov 24;65(22):15391-15415.

Molecular Formula	C₂₆H₂₆ClN₃O₄
Molecular Weight	479.96