2249935-19-9

2249935-19-9 structure

Name: Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
Chemical Name: Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
CAS Number: 2249935-19-9
Molecular Formula: C₅₁H₆₅N₁₇O₁₉P₂S_2.xC₆H₁₅N
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2023-01-19 00:28:11
Modify Date: 2024-04-09 09:49:37
Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1].

Name	Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine

Description	Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Immunology/Inflammation >> STING
Target	HER2
In Vitro	STING（干扰素基因刺激物）是一种促进先天免疫信号传导的内质网衔接子。据报道，STING 包含四个假定的跨膜区域，主要位于内质网中，能够激活 NF-kB、STAT6 和 IRF3 转录途径以诱导 I 型干扰素 (例如 IFN-α 和 IFN-β) 的表达并在表达后发挥有效的抗病毒状态。相反，STING 的缺失使小鼠胚胎成纤维细胞极易受到负链病毒感染，包括水疱性口炎病毒[1]。
References	[1]. Thomas W. Dubensky Jr., et al. Antibody conjugates comprising sting agonist. WO2018200812A1.

Molecular Formula	C₅₁H₆₅N₁₇O₁₉P₂S_2.xC₆H₁₅N