Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BRD7586
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: BRD7586
Price: ￥550.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

895460-70-5

895460-70-5 structure

895460-70-5 structure

Name: BRD7586
Chemical Name: 3-(4-chlorophenyl)sulfonyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)propanamide
CAS Number: 895460-70-5
Molecular Formula: C₁₇H₁₄ClN₃O₃S₂
Molecular Weight: 407.89436
Catalog: Signaling Pathways Cell Cycle/DNA Damage CRISPR/Cas9
Create Date: 2023-01-19 17:57:04
Modify Date: 2024-09-25 19:27:46
BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9. BRD7586 is the smallest known anti-CRISPR[1].

Name	3-(4-chlorophenyl)sulfonyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)propanamide

Description	BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9. BRD7586 is the smallest known anti-CRISPR[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> CRISPR/Cas9
In Vitro	BRD7586在细胞中特异性地与 SpCas9 结合，但不与 Cas12a 结合[1]。 BRD7586 (0-20 μM; 24 h) 在 HiBiT-knock-in 试验中，呈剂量依赖性地抑制 SpCas9[1]。 BRD7586 (20 μM; 48 h) 增强 HEK293T 细胞中中靶与脱靶的比值[1]。
References	[1]. Lim D, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022 Dec;24(12):1766-1775.

Molecular Formula	C₁₇H₁₄ClN₃O₃S₂
Molecular Weight	407.89436