2785404-83-1
2785404-83-1 structure
- Name: HDAC6 degrader-3
- Chemical Name: HDAC6 degrader-3
- CAS Number: 2785404-83-1
- Molecular Formula: C41H41F4N7O11
- Molecular Weight: 883.80
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2023-02-02 13:40:18
- Modify Date: 2024-04-12 09:52:03
-
HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin[1].
| Name | HDAC6 degrader-3 |
|---|
| Description | HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC6:19.4 nM (ID50) HDAC6:4.54 nM (IC50) HDAC1:0.647 μM (IC50) Cereblon |
| In Vitro | HDAC6 degrader-3 (化合物 B4; 100-1000 nM; 24 小时) 表现出有效的 HDAC6 降解以及 α-微管蛋白的高度乙酰化[1]。 HDAC6 degrader-3 (0.5-50 μM; 72 小时) 对白血病细胞系 (697、HL-60、KASUMI-1、MV4-11、REH、THP-1、SKNO- 1, MOLM-13)[1]。 Western Blot Analysis[1] Cell Line: U266 multiple myeloma cell line Concentration: 100 nM and 1000 nM Incubation Time: 24 h Result: Demonstrated potent HDAC6 degradation as well as hyperacetylation of α-tubulin. |
| References |
| Molecular Formula | C41H41F4N7O11 |
|---|---|
| Molecular Weight | 883.80 |