1957235-57-2
1957235-57-2 structure
- Name: Thalidomide-NH-(CH2)2-NH-Boc
- Chemical Name: N-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester
- CAS Number: 1957235-57-2
- Molecular Formula: C20H24N4O6
- Molecular Weight: 416.43
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2023-03-10 08:48:17
- Modify Date: 2024-01-19 18:13:38
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Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
| Name | N-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester |
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| Description | Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
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| Related Catalog |
| Molecular Formula | C20H24N4O6 |
|---|---|
| Molecular Weight | 416.43 |
| Appearance | Solid | Yellow |
| Water Solubility | Dichloromethane, Ethyl Acetate, Methanol |