Thalidomide-NH-(CH2)2-NH-Boc

Modify Date: 2024-01-19 18:13:38

Thalidomide-NH-(CH2)2-NH-Boc structure	Common Name	Thalidomide-NH-(CH2)2-NH-Boc
	CAS Number	1957235-57-2	Molecular Weight	416.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-NH-(CH2)2-NH-Boc

Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

Name	N-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester

Description	Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Molecular Formula	C₂₀H₂₄N₄O₆
Molecular Weight	416.43
Appearance of Characters	Solid \| Yellow
Water Solubility	Dichloromethane, Ethyl Acetate, Methanol