Shanghai Nianxing Industrial Co., Ltd
China
Product Name: domagrozumab
Price:
Purity: 95.0%
Stocking Period: 10 Day
Contact: Yang

1629605-31-7

1629605-31-7 structure

1629605-31-7 structure

Name: Domagrozumab
Chemical Name: Domagrozumab
CAS Number: 1629605-31-7
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Metabolic Disease
Create Date: 2023-03-01 13:05:27
Modify Date: 2024-04-09 16:21:18
Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1].

Name	Domagrozumab

Description	Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Domagrozumab (PF-06252616) 抑制人肌肉生长抑制素信号传导活性，IC50 值为 < 1 nM[1]。
In Vivo	Domagrozumab (PF-06252616; 10 and 30 mg/kg; i.v.) 以剂量依赖性方式增加肌肉生长抑制素水平并诱导食蟹猴骨骼肌肥大[1]。
References	[1]. St Andre M, et, al. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys. Skelet Muscle. 2017 Nov 9;7(1):25.

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