Domagrozumab

Modify Date: 2024-04-09 16:21:18

Domagrozumab Structure
Domagrozumab structure
Common Name Domagrozumab
CAS Number 1629605-31-7 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Domagrozumab


Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1].

 Names

Name Domagrozumab

 Domagrozumab Biological Activity

Description Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1].
Related Catalog
In Vitro Domagrozumab (PF-06252616) 抑制人肌肉生长抑制素信号传导活性,IC50 值 为 < 1 nM[1]。
In Vivo Domagrozumab (PF-06252616; 10 and 30 mg/kg; i.v.) 以剂量依赖性方式增加肌肉生长抑制素水平并诱导食蟹猴骨骼肌肥大[1]。
References

[1]. St Andre M, et, al. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys. Skelet Muscle. 2017 Nov 9;7(1):25.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties