698346-43-9
698346-43-9 structure
- Name: 84-B10
- Chemical Name: 84-B10
- CAS Number: 698346-43-9
- Molecular Formula: C25H22F3NO5
- Molecular Weight: 473.44
- Catalog: Signaling Pathways Apoptosis Ferroptosis
- Create Date: 2023-04-15 12:00:43
- Modify Date: 2024-01-14 16:22:24
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84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1].
| Name | 84-B10 |
|---|
| Description | 84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1]. |
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| Related Catalog | |
| In Vitro | 84-B10 (10-100 μM; 2 h) 以剂量依赖性方式抑制顺铂诱导的肾小管上皮细胞铁死亡[1]。 84-B10 (40 μM; 2 小时; TKPT 细胞) 恢复顺铂诱导的线粒体结构损伤和功能障碍[1]。 84-B10 (40 μM; 2 小时; TKPT 细胞) 减轻顺铂诱导的 AKI 中 mtROS 诱导的氧化应激[1]。 84-B10 (40 μM; 2 小时; TKPT 细胞) 通过消除 mtROS 和恢复线粒体稳态来减轻顺铂诱导的上皮细胞损伤[1]。 Western Blot Analysis[1] Cell Line: tubular epithelial cell Concentration: 10, 20, 30, 40, 50, and 100 μM Incubation Time: 2 hours Result: Increased the levels of NRF2, SLC7A11, and GPX4 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: TKPT cells Concentration: 40 μM Incubation Time: 2 hours Result: Increased the levels of OM Porins, IMS Cyt c, IM CVa, IM Core 1, and Matrix CypD in a dose-dependent manner. |
| In Vivo | 84-B10 (5-15 mg/kg; i.p.) 减轻顺铂诱导的小鼠急性肾损伤[1]。 Animal Model: Male C57BL/6 mice with acute kidney injury[1] Dosage: 5, 10, and 15 mg/kg Administration: intraperitoneal injection Result: Decreased the sCr and BUN levels of cisplatin-exposed mice. Attenuated renal tubules morphological abnormalities in a dose-dependent manner. Decreased NGAL and KIM-1 levels in a dose-dependent manner. Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1. |
| References |
| Molecular Formula | C25H22F3NO5 |
|---|---|
| Molecular Weight | 473.44 |