2131038-11-2
2131038-11-2 structure
- Name: Insulin efsitora alfa
- Chemical Name: Insulin efsitora alfa
- CAS Number: 2131038-11-2
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Insulin Receptor
- Create Date: 2023-04-05 13:27:37
- Modify Date: 2024-07-18 11:56:28
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Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes patients[1].
| Name | Insulin efsitora alfa |
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| Description | Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes patients[1]. |
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| Related Catalog | |
| In Vitro | Insulin efsitora alfa (0.01-100 nM) 在 HEK293 细胞中刺激人胰岛素受体同种型 A (hIR-A) 和人胰岛素受体亚型 B (hIR-B) 磷酸化，EC50 值分别为 4241 nM和 391 nM[2]。 Insulin efsitora alfa (20 µM；30 min) 显著促进 hIR-A 和 hIR-B 去磷酸化[2]。 Insulin efsitora alfa 刺激 3T3-L1 脂肪细胞的脂质生成和 SAOS-2 与 H4IIE 细胞的细胞增殖，EC50 值分别为 19 nM、134 nM 和 20 nM[2]。 |
| In Vivo | Insulin efsitora alfa (3、10 和 30 nmol/kg；皮下注射；单剂量) 在使用链脲佐菌素 (Streptozotocin，HY-13753) 治疗的糖尿病大鼠中显著降低了血糖[2]。 |
| References |
| No Any Chemical & Physical Properties |