1628543-40-7

1628543-40-7 structure

Name: Maytansinoid B
Chemical Name: Maytansinoid B
CAS Number: 1628543-40-7
Molecular Formula: C₃₆H₅₁ClN₄O₁₀
Molecular Weight: 735.26
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2023-04-03 16:18:03
Modify Date: 2024-04-08 15:24:37
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form Antibody-Drug Conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis[1][2].

Name	Maytansinoid B

Description	Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form Antibody-Drug Conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
In Vitro	Maytansinoid 对包括淋巴瘤系在内的几种肿瘤细胞系表现出 10-90 pM 的细胞毒活性[1]。 Maytansinoid 与抗 CD9 抗体结合，可形成 SAR3419 对抗 B 细胞恶性肿瘤[1]。
References	[1]. Blanc V, et al. SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res. 2011 Oct 15;17(20):6448-58. [2]. Andreev Julian, et al. Bispecific antigen binding molecules that bind HER2, and methods of use thereof: World Intellectual Property Organization, WO2021174113. 2021-09-02.

Molecular Formula	C₃₆H₅₁ClN₄O₁₀
Molecular Weight	735.26