1504558-72-8

1504558-72-8 structure

1504558-72-8 structure

Name: Nec-3a
Chemical Name: Nec-3a
CAS Number: 1504558-72-8
Molecular Formula: C₂₁H₁₈F₄N₂O₄
Molecular Weight: 438.37
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2023-04-03 22:45:58
Modify Date: 2024-07-22 20:48:26
Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

Name	Nec-3a

Description	Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase
Target	RIPK1:0.44 μM (IC50)
References	[1]. Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.

Molecular Formula	C₂₁H₁₈F₄N₂O₄
Molecular Weight	438.37