265650-93-9

265650-93-9 structure

Name: vMIP-II (1-21)
Chemical Name: vMIP-II (1-21)
CAS Number: 265650-93-9
Molecular Formula: C₁₀₈H₁₆₉N₃₃O₂₇S
Molecular Weight: 2425.84
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2023-04-07 07:41:07
Modify Date: 2024-04-07 18:15:26
vMIP-II (1-21) is a CXCR4 antagonist. vMIP-II has broad-spectrum interaction with CC and CXC chemokine receptors. vMIP-II (1-21) binds with CXCR4 with an IC50 value of 190 nM for competing with CXCR4 binding of 125I-SDF-1R[1].

Name	vMIP-II (1-21)

Description	vMIP-II (1-21) is a CXCR4 antagonist. vMIP-II has broad-spectrum interaction with CC and CXC chemokine receptors. vMIP-II (1-21) binds with CXCR4 with an IC50 value of 190 nM for competing with CXCR4 binding of 125I-SDF-1R[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
In Vitro	vMIP-II (1-21) (0.01-10 μM) 可与趋化因子受体 CXCR4 结合[1]。 vMIP-II (1-21) (25-200 μM) 抑制 CXCR4 介导 T 和双亲性 HIV-1 gp120 介导的细胞-细胞融合[1]。 vMIP-II (1-21) (100 μM) 剂量依赖性地抑制的趋化活性[1]。
References	[1]. Zhou N, ey al. A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II. Biochemistry. 2000 Apr 4;39(13):3782-7.

Molecular Formula	C₁₀₈H₁₆₉N₃₃O₂₇S
Molecular Weight	2425.84