2914922-83-9
2914922-83-9 structure
- Name: Anticancer agent 99
- Chemical Name: Anticancer agent 99
- CAS Number: 2914922-83-9
- Molecular Formula: C19H20F3N3O2
- Molecular Weight: 379.38
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-05-15 12:23:58
- Modify Date: 2024-04-03 18:33:13
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Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect[1].
| Name | Anticancer agent 99 |
|---|
| Description | Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect[1]. |
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| Related Catalog | |
| In Vitro | Anticancer agent 99 (0-50 μM, 24 h)可直接上调 Bax 表达并诱导 HepG2 细胞系中的 caspase-3 依赖性细胞凋亡，具有抗增殖作用[1]。 Apoptosis Analysis[1] Cell Line: HepG2 cell Concentration: 25, 50 μM Incubation Time: 24 h Result: Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes. Reduced Akt protein levels in HepG2 cells. Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells. |
| References |
| Molecular Formula | C19H20F3N3O2 |
|---|---|
| Molecular Weight | 379.38 |