1217696-12-2

1217696-12-2 structure

Name: Fmoc-His(Trt)-OH-15N3
Chemical Name: Fmoc-His(Trt)-OH-15N3
CAS Number: 1217696-12-2
Molecular Formula: C₄₀H₃₃₁₅N₃O₄
Molecular Weight: 622.69
Catalog: Research Areas Others
Create Date: 2023-05-12 19:42:31
Modify Date: 2024-01-18 10:00:20
Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].

Name	Fmoc-His(Trt)-OH-15N3

Description	Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.

Molecular Formula	C₄₀H₃₃₁₅N₃O₄
Molecular Weight	622.69