Name | Ladostigil hydrochloride |
---|
Description | Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease[1][2]. |
---|---|
Related Catalog | |
Target |
AChE:31.8 μM (IC50) MAO-B:37.1 μM (IC50) |
In Vitro | Ladostigil (1-10 µM) hydrochloride 具有神经保护活性,包括防止线粒体膜电位 (ψ) 下降,衰减凋亡级联和抑制 OS 损伤诱导的 ROS 产生[2]。 Ladostigil (1-10 µM) hydrochloride 具有显著的神经保护活性,包括抑制 caspase-3 激活,诱导 Bcl-2,降低人成神经细胞瘤 SK-N-SH 细胞中 Bad 和 Bax 基因和蛋白的表达[2]。 |
In Vivo | Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hydrochloride 在从青春期到产前压力大鼠的成年期的高架十字迷宫 (EPM) 和强迫游泳测试 (FST) 测试中,消除了他们的高度焦虑和抑郁样行为[4]。 Ladostigil (50 μmol/kg; single p.o.) hydrochloride 在大鼠物体识别测试中恢复丧失的情景记忆[3]。 Animal Model: Pathogen-free (SPF) Sprague-Dawley rats[4] Dosage: 17 mg/kg Administration: Oral (added to the drinking water) daily for 6 weeks Result: Inhibited brain MAO-A and B by more than 60%. Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. |
References |
Molecular Formula | C16H21ClN2O2 |
---|---|
Molecular Weight | 308.80 |